Human beings are works in progress that mistakenly think they are finished
ChemBio Discovery was founded by Dr. Santosh Khedkar to help entrepreneurs and their organizations to accelerate drug discovery and development process, and to help small-to-medium size research organizations reduce overhead costs of employing full-time high skilled experts and setting up in-house CADD lab. He designed a flexible and competitive consulting model to suit clients' research needs, has served several clients accelerate their drug discovery pipeline.
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Dr. Santosh Khedkar is an experienced Computational Chemist with basic training in pharmacy and medicinal/ synthetic chemistry, and a track record of success in a decade of research in industry (Imclone Systems, Eli Lilly, Dr. Reddy’s Laboratories, Piramal Life Sciences) and academia (Beth Israel Deaconess Medical Center, Harvard Medical School). He discovered and developed several lead molecules and is actively engaged in research projects involving scientists of diverse background such as Organic Chemistry, Biology, Biochemistry, Pharmacokinetics and Toxicity. Dr. Khedkar has authored over 25 articles in peer-reviewed scientific journals (Scientific Reports, J. Med. Chem., J. Chem. Inf. Model., J. Comput.-Aided Mol. Des., Nature Commun.), and three published US patents. 

SUMMARY
§  Highly motivated and passionate computational chemist with Ph.D. degree in Pharmaceutical Chemistry and over 9 years of industry and post-doctoral research experience.  Successful track record of progressing discovery projects by applying computational modeling methods.  Recognized for excellence, integrity, proactivity, and commitment to meeting deadlines.
§  Hit-to-lead identification, lead optimization, candidate selection.
§  Structure-based design, binding energy calculations, MD simulations, pharmacophore mapping,             molecular and P-P docking, virtual screening.
§  Descriptor-based mathematical modeling (QSAR/QSPR) to build predictive/ statistical models.
§  Sound knowledge of medicinal chemistry and its application in addressing design challenges.
§  Modeling of macrocyclic compounds' binary/ ternary binding, nucleic acid (phosphoramidite)               chemistry, RNA modeling, mRNA translation inhibition; designing of complex workflows.
§  Biologics: antibody modeling, protein-protein docking, thermal stability, affinity maturation.
§  Proficiency in modeling suites: Schrodinger, MOE, BioSolveIT, Tripos, Gaussian.
§  Application of data analytics and management tools: Canvas, Spotfire, DataWarrior, KNIME, R.
§  Synthesis and purification of small organic molecules (early career experience). Familiarity with           Linux, Mac and Windows platform administration.
§  Excellent written & oral communication, presentation and project management skills.
RESEARCH EXPERIENCE
§ 02/2014 –         : Founder & President, ChemBio Discovery, Inc.; Computational Chemistry & Structural Biology. Lexington, MA (Greater-Boston area).
§ 01/2011–01/2014 : Senior Scientist, Computational Discovery & Chemistry; ImClone Systems, a wholly-owned subsidiary of Eli Lilly & Co., New York, NY.
§ 05/2008–01/2011 : Research Fellow; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
§ 02/2007–02/2008 : Research Scientist - Cheminformatics; Piramal Life Sciences Ltd., Mumbai.
§ 03/2002–06/2003 : Research Chemist; Dr. Reddy’s Laboratories Ltd., Hyderabad.
EDUCATION
§ 05/2008–01/2011   : Post-doctorate Fellow, Harvard Medical School, Boston, MA.
§ 06/2003–02/2007 : Ph. D.  (Pharmaceutical Chemistry); Bombay College of Pharmacy, University of Mumbai.
§ 08/1999–08/2001   : M. S.  (Pharmaceutical Chemistry); Institute of Chemical Technology, Uni. of Mumbai.