​"Research is seeing what everybody else has seen and thinking what nobody else has thought."

PATENTS
1. Vivek Vishnudas, Dinesh Chimmanamada, Santosh Khedkar; WO2021138540; UbE2K Modulators and Methods for Their Use. Issued July 8, 2021.
2. Lan Huang, Santosh Khedkar, Michel Steinmetz; WO2018/129381; Tubulin Binding Compounds and Therapeutic Use Thereof. Issued July 12, 2018.
3. Radhakrishnan Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Rayomand Gimi, Dillon Cleary, Santosh Khedkar, SreeRupa Challa; WO2017/123766; Compounds and Compositions for the Treatment of Disease. Issued July 20, 2017.
4. Mark Feinberg and Santosh Khedkar; US20170121318 (Appl. No. 15/337,633); Use of Small Molecule Inhibitors to KLF10 for Modulation of T Regulatory Cells and Cancer Immunotherapy. (filed 28 October 2016, Issued May 4, 2017).
5. Peter Kang, Ananth S Karumanchi, Alan Rigby, Santosh Khedkar, Ravi Thandhani; WO2013009799 (US20140378507); Vitamin D Receptor Agonists and Uses Thereof. Issued January 17, 2013.

PUBLICATIONS
1. Khedkar SA, Samad, MA, Choudhary S, Lee JY, Zhau D, Thandhani RI, Karumanchi SA, Rigby AC, Kang PM. Identification of Novel Non-secosteroidal Vitamin D Receptor Modulators with cardioprotective property without calcemic effect. Scientific Reports 2017, 7(1): 8427.
2. Kain V, Liu F, ‎ Kozlovskaya V, Ingle KA, Bolisetty S, Agarwal A, Khedkar S, Prabhu SD, Kharlampieva E, and Halade GV. Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing. Scientific Reports 2017, 7, 9999.
3. Bezzerides V, Zhang A, Simonson B, Xiao L, Khedkar SA, Ottaviano F, Lynch S, Hessler K, Milan D, Rigby AC, Das S, and Rosenzweig A. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Scientific Reports 2017, 7, 346.
4. Khedkar SA, Sun X, Rigby AC, Feinberg MW. Discovery of Small Molecule Inhibitors to Krüppel-Like Factor 10 (KLF10): Implications for Modulation of T Regulatory Cell Differentiation. J Med Chem 2015, 58(3):1466-1478.
5. Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Khedkar SA, Datta M, Sherris D, Prendergast GC, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA, Benjamin LE. RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nature Commun 2013, 4:2824.
6. Verma J, Malde AK, Khedkar SA, Coutinho EC. Comparative Occupancy Analysis (CoOAn) - A straightforward and directly applicable 3D-QSAR formalism to extract molecular features obligatory for designing potent leads. Mol Inf 2012, 31(6-7):431-442.
7. Thadhani RI, Kisner T, Hagmann H, Bossung V, Noack S, Schaarschmidt W, Jank A, Kribs A, Cornely OA, Kreyssig C, Hemphill L, Rigby AC, Khedkar SA, Lindner TH, Mallmann P, Stepan H, Karumanchi SA, Benzing T. Pilot study of extracorporeal removal of soluble Fms-like Tyrosine Kinase 1 in Preeclampsia. Circulation 2011, 124(8):940-950. Response to letters: Circulation 2012, 125:e523.
8. Khedkar SA. Current computational approaches in medicinal chemistry. An editorial to special thematic issue. Curr Top Med Chem 2010, 10 (1):1–2. (Guest Editorial)
9. Patil SP, Maki S, Khedkar SA, Rigby AC, Chan C. Withanolide-A and asiatic acid modulate multiple targets associated with AβPP processing and Aβ clearance. J Nat Prod 2010, 73(7):1196-1202.
10. Talele TT, Khedkar SA, Rigby AC. Successful Applications of Computer Aided Drug Discovery: Moving Drugs from Concept to the Clinic. Curr Top Med Chem 2010, 10(1):127-141.
11. Verma J, Malde AK, Khedkar SA, Iyer RP, Coutinho EC. Local Indices for Similarity Analysis (LISA)- a 3D-QSAR formalism based on local molecular similarity. J Chem Inf Model 2009, 49(12):2695-2707.
12. Suji G, Khedkar SA, Singh SK, Kishore N, Coutinho EC, Bhor VM, Sivakami S. Binding of lipoic acid induces conformational change and appearance of a new binding site in methylglyoxal modified serum albumin. Protein J 2008, 27(4):205-214.
13. Verma J, Khedkar VM, Prabhu AS, Khedkar SA, Malde AK, Coutinho EC. A Comprehensive Analysis of the Thermodynamic Events involved in Ligand-Receptor Binding using CoRIA and its variants. J Comput-Aided Mol Des 2008, 22(2):91-104.
14. Khedkar SA, Malde AK, Coutinho EC. Design of Inhibitors against MurF Enzyme of S. pneumoniae using Docking, 3D-QSAR and De Novo Design. J Chem Inf Model 2007, 47(5):1839-1846.
15. Khedkar SA, Malde AK, Coutinho EC, Srivastava S. Pharmacophore Modeling in Drug Discovery and Development: An Overview. Med Chem 2007, 3:187-197.
16. Khedkar SA, Malde AK and Coutinho EC. Inhibition of methionine-S-adenosyltransferase of M. smegmatis and M. tuberculosis: Homology Modelling, Docking and De novo Inhibitor Design. Internet Electron J Mol Des 2007, 6:151-156.
17. Khedkar SA, Malde AK, Coutinho EC. CoMFA Study of Distamycin Analogs Binding to the Minor-groove of DNA: A Unified Model for Broad-spectrum Activity. J Mol Model 2007, 13(10):1099-1108.
18. Malde AK, Khedkar SA, Coutinho EC. The B(OH)-NH Isostere is a Surrogate for the Amide bond (CO-NH) in Peptides: An Ab Initio Study. J Chem Theory Comput 2007, 3(2):619-627.
19. Pissurlenkar RRS, Malde AK, Khedkar SA, Coutinho EC. Encoding Type and Position in Peptide QSAR: Application to peptides binding to Class I MHC Molecule HLA-A*0201. QSAR & Comb Sci 2007, 26(2):189-203.
20. Malde AK, Khedkar SA, Coutinho EC. Isosteres of Peptides – Boron analogs as Dipolar forms of α-amino acids: An Ab Initio Study. J Phys Org Chem 2007, 20(2):151–160.
21. Khedkar SA, Malde AK, Coutinho EC. In Silico Screening of Ligand Databases: Methods and Applications. Indian J Pharm Sci 2006, 68(6):689-689.
22. Malde AK, Khedkar SA, Coutinho EC. Stationary points on the PES of N-methoxy Peptides and their Boron Isosteres: An Ab Initio Study. J Chem Theory Comput 2006, 2(6):1664-1674.
23. Datar PA, Khedkar SA, Malde AK, Coutinho EC. Comparative Residue Interaction Analysis (CoRIA): A 3D-QSAR Approach to Explore the Binding Contributions of Active Site Residues with Ligands. J Comput-Aided Mol Des 2006, 20(6):343-360.
24. Khedkar SA, Malde AK, Coutinho EC. Topology of Human Methionine S-Adenosyltransferase. Indian J Chem A 2006, 45(1):138-145.
25. Malde AK, Khedkar SA, Coutinho EC. The ω, φ and ψ space of N-hydroxy-N-methylacetamide and N-acetyl-N'-hydroxy-N'-methylamide of alanine and their boron isosteres. J Chem Theory Comput 2006, 2(2):312-321.
26. Khedkar SA, Malde AK, Coutinho EC. Modeling Human Neurokinin-1 Receptor Structure using the Crystal Structure of Bovine Rhodopsin. Internet Electron J Mol Des 2005, 4(5):329-341.
27. Malde AK, Khedkar SA, Coutinho EC, Saran A. Geometry, Transition States and Vibrational Spectra of Boron Isostere of N-Methylacetamide by Ab Initio Calculations. Int J Quantum Chem 2005, 102(5):734-742.
28. Khedkar SA, Malde AK, Coutinho EC. Comparative Protein Modeling of Methionine S-Adenosyltransferase (MAT) Enzyme from M. tuberculosis: A Potential Target for Antituberculosis Drug Discovery. J Mol Graph Model 2005, 23(4):355-366.